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| Bortman,P.; Folgueira,M.A.A.K.; Katayama,M.L.H.; Snitcovsky,I.M.L.; Brentani,M.M.. |
| The hormone 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3), the active form of vitamin D3, is an important regulator of calcium homeostasis, exerts antiproliferative effects on various cell systems and can induce differentiation in some kinds of hematopoietic cells. These effects are triggered by its receptor, vitamin D receptor (VDR), a phosphoprotein member of the nuclear receptor superfamily, which functions as a transcriptional factor. VDR binds as a heterodimer with retinoid X receptor (R X R) to hexameric repeats, characterized as vitamin D-responsive elements present in the regulatory region of target genes such as osteocalcin, osteopontin, calbindin-D28K, calbindin-D9K, p21WAF1/CIP1, TGF-ß2 and vitamin D 24-hydroxylase. Many factors such as... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Calcitriol; Calcitriol receptor; Calcitriol analog; Breast tumor; Cell proliferation. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100001 |
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| Alves,Osvanira dos Santos; Calixto,Ligia Fatima Lima; Araujo,Alexandre Herculano Borges; Torres-Cordido,Karoll Andrea Alfonso; Reis,Túlio Leite; Calderano,Arele Arlindo. |
| ABSTRACT: An experiment was performed to evaluate the effect of decreased levels of vitamin D3 in the premix and 1,25-dyhydroxyvitamin D3-glycoside (1,25(OH)2D3-glycoside) supplementation on performance, carcass yield and bone quality in 42d old broilers. Seven-d-old male chickens Cobb500® were distributed in a randomized design with six treatments: a control diet with inclusion of vitamin D3 in the premix, without supplementation of 1,25(OH)2D3-glycoside, and five diets with decreased levels of vitamin D3 (100%, 75%, 50%, 25% and 0% about the control) plus the addition of 1,25(OH)2D3-glycoside, 50g ton-1 of diet. The main results were to reduce the tenor of Vitamin D3 in the premix when the addition of 1,25(OH)2D3-glycoside did not affect (P>0.05) the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bone growth; Bone strength; Calcitriol; Poultry; Solanum glaucophylum.. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000800651 |
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| Folgueira,M.A.A.K.; Federico,M.H.H.; Roela,R.A.; Maistro,S.; Katayama,M.L.H.; Brentani,M.M.. |
| A close correlation between vitamin D receptor (VDR) abundance and cell proliferation rate has been shown in NIH-3T3 fibroblasts, MCF-7 breast cancer and in HL-60 myeloblastic cells. We have now determined if this association occurs in other leukemic cell lines, U937 and K562, and if VDR content is related to c-myc expression, which is also linked to cell growth state. Upon phorbol myristate acetate (PMA) treatment, cells from the three lineages (HL-60, U937 and K562) differentiated and expressed specific surface antigens. All cell lines analyzed were growth inhibited by PMA and the doubling time was increased, mainly due to an increased fraction of cells in the G0/G1 phase, as determined by flow cytometry measurements of incorporated bromodeoxyuridine and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Receptors; Calcitriol; Cell division; Cell differentiation; Leukemia; Phorbol esters. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000500011 |
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| Souza,C.S.; Vieites,F.M.; Vasconcellos,C.H.F.; Calderano,A.A.; Nunes,R.V.; Ferreira,C.M.; Pereira,T.V.S.; Moraes,G.H.K.. |
| Avaliaram-se o desempenho e o rendimento de carcaça e cortes nobres de frangos de corte machos com suplemento nas rações de 1,25 dihidroxicolecalciferol e redução de cálcio e fósforo disponível. Foi utilizado um delineamento em blocos ao acaso, com seis tratamentos: 0,0; 1,0; 2,0; 3,0; 4,0 e 5,0µg de vitamina D3 ativa/kg de ração, e seis repetições com 17 aves cada. Aos 8 e 42 dias de idade cada unidade experimental foi pesada para avaliação do desempenho. Posteriormente, quatro aves/repetição foram retiradas e abatidas para mensuração do rendimento de carcaça e de cortes nobres. A inclusão da vitamina D3 ativa influenciou positivamente (P<0,05) o ganho de peso e a conversão alimentar com as suplementações de 1,0 e 2,0µg/kg. O consumo de ração não... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Avicultura; Calcitriol; Carcaça; Desempenho; Vitamina D. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352013000200031 |
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